IMMUNOLOGY2025™ Conference Recordings-Autoantibody deposition in the neurovasculature promotes interferon-? release to drive neuropsychiatric lupus

Autoantibody deposition in the neurovasculature promotes interferon-? release to drive neuropsychiatric lupus - Stacie Lin

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Video Summary

Stacey described her thesis work on neuropsychiatric lupus in SLE1.YAA mice. She found that type 1 interferon signatures appear early in the brain, in patch-like regions, before the peripheral interferon response. These patches correlate with autoantibody and immune complex deposition at the blood-brain barrier, especially with C1q complement activation, astrocyte reactivity, and myeloid cell recruitment. Transferring lupus serum or antibody-secreting cells into healthy mice reproduced brain immune complex deposition, interferon responses, and mild anxiety-like behavior. Complement knockout blocked these effects, suggesting immune complexes and complement drive CNS inflammation and behavioral symptoms.

Keywords

neuropsychiatric lupus

type 1 interferon

immune complex deposition

blood-brain barrier

complement activation